Pharmacotherapeutic Effect of Stress Protectors in the Age Aspect

Alina Holovanova, Liudmyla Kyrychek, Tamara Yermolenko, Fedir Hladkykh

Abstract

The data of the literature and the results of original experimental observations concerning the age aspects of stress reactions that accompany a person from birth to adulthood are given. Stress in children is emotional and is characterized by an increase in the thymus, as well as an increase in the level of corticosteroids in the blood, as a reflection of the innate immune-lymphoid defense of the child, which occurs in the process of the childbirth stress of mother. Other indicators of neurohormonal protection (adrenal glands, spleen, eosinopenia, hyperglycemia) are typical but less pronounced than in adults due to functional immaturity of systems and organs. The shift in the balance of the prooxidant-antioxidant system is not marked. In addition, "child" stress is manifested by deficiency of magnesium (Mg2+), a violation of the acid balance and immune deficiency. The above data serve as the basis for the proof of the need of involving in everyday complex therapy of any disease, depending on the indications, along with formulary preparations in children's doses of herbal sedatives (Valeriana officinalis, Cardamine pratensis), psycho-responsive tranquilizers and even neuroleptics, magnesium preparations, Echinacea in combination with Zinc and vitamin C. Also antioxidants, immunostimulants and stressors (piracetam, aminolon, taurine), plant adaptogenes (Panax, Eleutherococcus), which prevent a stress reaction, without violating the level of innate protection of the growing organism and the child's mental abilities at the level of its physical development, are recommended.



Keywords


stress; stress prorotector; piracetam; eleuterococcus; "child" stress; comparative age experiment; adaptogenes; immobilization



References


1. Ahmad, A., Rasheed, N., Chand, K., Maurya, R., Banu, N., & Palit, G. (2012). Restraint stress-induced central monoaminergic and oxidative changes in rats and their prevention by novel Ocimum sanctum compounds. Indian Journal of Medical Research, 135, 548–554.

[Google Scholar]

2. Baraboi, V., Reznikov, O. (2013). Fiziolohiia, biokhimiia i psykholohiia stres [Physiology, biochemistry and psychology of stress]. Kyiv: Interservis (in Ukrainian)
[Барабой, В., Резніков, О. (2013). Фізіологія, біохімія і психологія стрес. Київ: Інтерсервіс].

[Google Scholar]

3. Belenichev, I., Sereda D., Dejnichenko, Ju., Buhtijarova, P., Pavlov, S., & Kucherenko, L. (2010). Sovremennye nootropnye preparaty: klassifikacija, mehanizm dejstvija, perspektivy primenenija [Modern nootropic drugs: classification, mechanism of action, prospects of use]. Zaporozhskij medicinskij zhurnal, 5, 122–126 (in Russian)
[Беленичев, И., Середа Д., Дейниченко, Ю., Бухтиярова, П., Павлов, С., & Кучеренко, Л. (2010). Современные ноотропные препараты: классификация, механизм действия, перспективы применения. Запорожский медицинский журнал, 5, 122–126].

[Google Scholar]

4. Brjazgunov, I., Kizeva, E. (2013). Posttravmaticheskoe stressovoe rasstrojstvo v praktike pediatra [Posttraumatic stress disorder in a pediatrician’s practice]. Vrach, 3, 71–73 (in Russian)
[Брязгунов, И., Кизева, Е. (2013). Посттравматическое стрессовое расстройство в практике педиатра. Врач, 3, 71–73].

[Google Scholar]

5. Carrasco, G. A., & Van de Kar, L. D. (2003). Neuroendocrine pharmacology of stress. European Journal of Pharmacology, 463(1-3), 235–272.

[Google Scholar] [CrossRef]

6. Chen, H.-J. C., Spiers, J. G., Sernia, C., Anderson, S. T., & Lavidis, N. A. (2014). Reactive nitrogen species contribute to the rapid onset of redox changes induced by acute immobilization stress in rats. Stress, 17(6), 520–527.

[Google Scholar] [CrossRef]

7. Daviu, N., Rabasa, C., Nadal, R., & Armario, A. (2014). Comparison of the effects of single and daily repeated immobilization stress on resting activity and heterotypic sensitization of the hypothalamic–pituitary–adrenal axis. Stress, 17(2), 176–185.

[Google Scholar] [CrossRef]

8. Frolkis, V. (1991). Stress-vozrast-syndrom [Stress-age-syndrome]. Fiziolohichnyi zhurnal, 3, 3–10 (in Ukrainian)
[Фролькіс, В. (1991). Стресс-возраст-синдром. Фізіологічний журнал, 3, 3–10].

[Google Scholar]

9. Hladkykh, F. V., Stepaniuk, N. H., & Vernihorodskyi, S. V. (2016). Izuchenie sostojanija kletochnogo gomeostaza slizistoj obolochki zheludka krys na modeli revmatoidnogo artrita, lechennogo ibuprofenom i ego kombinaciej s vinboronom [The study of cell homeostasis state of the gastric mucosa of rats on model of rheumatoid arthritis, treatment with ibuprofen and its combination with vinboron]. Pharmacy & Pharmacology, 4(3), 68–83 (in Russian)
[Гладких, Ф. В., Степанюк, Н. Г., & Вернигородский, С. В. (2016). Изучение состояния клеточного гомеостаза слизистой оболочки желудка крыс на модели ревматоидного артрита, леченного ибупрофеном и его комбинацией с винбороном. Фармация и фармакология, 4(3), 68–83].

[Google Scholar] [CrossRef]

10. Hladkykh, F., Stepaniuk, N., & Vernygorodskyi, S. (2017). Macro- and Microscopic Study of the Effect of 2-Phenyl-3-Carbethoxy-4-Dimethylaminomethyl-5-Hydroxybenzofuran Hydrochloride (Vinboron) on the Gastrotoxicity of Ibuprofen in Experimental Rheumatoid Arthritis in Rats. Path of Science, 3(10), 7001–7018.

[Google Scholar] [CrossRef]

11. Isaev, D. (2005). Jemocional'nyj stress: psihosomaticheskie i somaticheskie rasstrojstva u detej [Emotional stress: psychosomatic and somatic disorders in children]. Saint-Petersburg: Rech' (in Russian)
[Исаев, Д. (2005). Эмоциональный стресс: психосоматические и соматические расстройства у детей. Санкт-Петербург: Речь].

[Google Scholar]

12. Kendjurina, E., Elkina, T., Shevchenko, M., & Tatarenko, Ju. (2012). Adaptacija rebenka k detskomu doshkol'nomu uchrezhdeniju (profilaktika ORVI v uslovijah stressa) [A child’s adaptation to a preschool institution: prevention of acute respiratory viral infections under stress]. Vrach, 5, 65–69 (in Russian)
[Кендюрина, Е., Елкина, Т., Шевченко, М., & Татаренко, Ю. (2012). Адаптация ребенка к детскому дошкольному учреждению (профилактика ОРВИ в условиях стресса). Врач, 5, 65–69].

[Google Scholar]

13. Kirichek, L. (1989). Jeksperimental'noe obosnovanie primenenija nejrotropnyh sredstv pri immobilizacii [Experimental substantiation of the use of neurotropic drugs for immobilization] (Doctoral dissertation). Retrieved from http://medical-diss.com/medicina/eksperimentalnoe-obosnovanie-primeneniya-neyrotropnyh-sredstv-pri-immobilizatsii (in Russian)
[Киричек, Л. (1989). Экспериментальное обоснование применения нейротропных средств при иммобилизации (Автореферат докторской диссертации). URL: http://medical-diss.com/medicina/eksperimentalnoe-obosnovanie-primeneniya-neyrotropnyh-sredstv-pri-immobilizatsii].

14. Kirichek, L., Abramova, L., Pisarenko, G., Polyakov, A., & Golovanova, A. (2015). Sostojanie stress-stimulirujushhih sistem u krys raznogo vozrasta pri immobilizacii i ego farmakologicheskaja korrekcija [Status of rat’s stress-stimulating systems of different ages in the immobilization and pharmacological correction]. Eksperimental'na і klіchna medicina, 3, 15–19 (in Russian)
[Киричек, Л., Абрамова, Л., Писаренко, Г., Поляков, А., & Голованова, А. (2015). Состояние стресс-стимулирующих систем у крыс разного возраста при иммобилизации и его фармакологическая коррекция. Експериментальна і клінічна медицина, 3, 15–19].

[Google Scholar]

15. Kirichek, L., Perepelica, A., & Kal'chuk, R. (2016). Lekarstvennyj antistress v jeksperimente (immobilizacija, travma, vospalenie) [Drug antistress in the experiment (immobilization, trauma, inflammation)]. Kharkov: Kontrast (in Russian)
[Киричек, Л., Перепелица, А., & Кальчук, Р. (2016). Лекарственный антистресс в эксперименте (иммобилизация, травма, воспаление). Харьков: Контраст].

[Google Scholar]

16. Lucassen, P. J., Pruessner, J., Sousa, N., Almeida, O. F. X., Van Dam, A. M., Rajkowska, G., … Czéh, B. (2013). Neuropathology of stress. Acta Neuropathologica, 127(1), 109–135.

[Google Scholar] [CrossRef]

17. Markova, I., & Kalinicheva, V. (1987). Pediatricheskaja farmakologija [Pediatric Pharmacology]. Moscow: Medicina (in Russian)
[Маркова, И., & Калиничева, В. (1987). Педиатрическая фармакология. Москва: Медицина].

[Google Scholar]

18. McEwen, B. S., & Gianaros, P. J. (2010). Central role of the brain in stress and adaptation: Links to socioeconomic status, health, and disease. Annals of the New York Academy of Sciences, 1186(1), 190–222.

[Google Scholar] [CrossRef]

19. Milenin, V. (2003). Psihosomaticheskie narushenija v detskom vozraste posle gospitalizacii [Posthospital psychosomatic disorders in children]. Anesteziologija i reanimatologija, 1, 69–73 (in Russian)

[Миленин, В. (2003). Психосоматические нарушения в детском возрасте после госпитализации. Анестезиология и реаниматология, 1, 69–73].

[Google Scholar]

20. Milenin, V. (2012). Predfaktory psihosomaticheskih narushenij v stomatologicheskoj praktike u detej [Factor previous of psychological disturbances in dental practice in children]. Rossijskij stomatologicheskij zhurnal, 4, 41–45 (in Russian)
[Миленин, В. (2012). Предфакторы психосоматических нарушений в стоматологической практике у детей. Российский стоматологический журнал, 4, 41–45].

[Google Scholar]

21. Nostramo, R., Tillinger, A., Saavedra, J. M., Kumar, A., Pandey, V., Serova, L., … Sabban, E. L. (2012). Regulation of angiotensin II type 2 receptor gene expression in the adrenal medulla by acute and repeated immobilization stress. Journal of Endocrinology, 215(2), 291–301.

[Google Scholar] [CrossRef]

22. Patchev, V., & Patchev, A. (2006). Experimental models of stress. Dialogues in Clinical Neuroscience, 8(4), 417–432.

[Google Scholar]

23. Sel'e, G. (1977). Novoe o gormonah i mehanizme ih dejstvija [New about hormones and the mechanism of their action]. Kiev: Naukova dumka (in Russian)

[Селье, Г. (1977). Новое о гормонах и механизме их действия. Киев: Наукова думка].

[Google Scholar]

24. Serhiienko, L. (2009). Rannii ontohenez – period «prohramuvannia» endokrynnykh ta hormonalno-zalezhnykh patolohii [Early ontogeny is a period of "programming" of endocrine and hormonal-dependent pathologies]. In Fundamentalna ta klinichna endokrynolohiia: problemy, zdobutky, perspektyvy (pp. 11–16). Kharkiv: n. d. (in Ukrainian)
[Сергієнко, Л. (2009). Ранній онтогенез – період «програмування» ендокринних та гормонально-залежних патологій. В Фундаментальна та клінічна ендокринологія: проблеми, здобутки, перспективи (с. 11–16). Харків: n. d.].

25. Shherban', N., Gorbach, T., Guseva, N. (2004). Laboratornye metodiki dlja izuchenija sostojanija antioksidantnoj sistemy i urovnja perikisnogo okislenija lipidov [Laboratory methods for studying the state of the antioxidant system and the level of lipid peroxidation]. Kharkov: HGMU (in Russian)
[Щербань, Н., Горбач, Т., Гусева, Н. (2004). Лабораторные методики для изучения состояния антиоксидантной системы и уровня перикисного окисления липидов. Харьков: ХГМУ].

[Google Scholar]

26. Stefanov, O. V. (Ed.). (2001). Doklinichni doslidzhennia likarskykh zasobiv [Preclinical studies of drugs]. Kyiv: Avitsena (in Ukrainian)
[Стефанов, О. В. (Ред.). (2001). Доклінічні дослідження лікарських засобів. Київ: Авіцена].

[Google Scholar]

27. Vogel, C., Silva, G. M., & Marcotte, E. M. (2011). Protein Expression Regulation under Oxidative Stress. Molecular & Cellular Proteomics, 10(12), M111.009217.

[Google Scholar] [CrossRef]

28. Wood, G. E., Norris, E. H., Waters, E., Stoldt, J. T., & McEwen, B. S. (2008). Chronic immobilization stress alters aspects of emotionality and associative learning in the rat. Behavioral Neuroscience, 122(2), 282–292.

[Google Scholar] [CrossRef]

29. Zapadnjuk, I., Zapadnjuk, V., Zaharija, E., & Zapadnjuk, B. (1983). Laboratornye zhivotnye: razvedenie, soderzhanie, ispol'zovanie v jeksperimente [Laboratory animals: breeding, content, use in experiment] (3d ed.). Kiev: Vishha shkola (in Russian)
[Западнюк, И., Западнюк, В., Захария, Е., & Западнюк, Б. (1983). Лабораторные животные: разведение, содержание, использование в эксперименте (3-e изд.). Киев: Вища школа].

[Google Scholar]

30. Zar, J. (2014). Biostatistical analysis (5th ed.). Upper Saddle River: Pearson.

[Google Scholar]

31. Zhyliuk, V., & Mamchur, V. (2011). Aktyvnist protsesiv vilnoradykalnoho okyslennia lipidiv i bilkiv v utvorenniakh holovnoho mozku pry khronichnii hiperhlikemii za umov zastosuvannia nootropnykh zasobiv [The activity of processes of free radical oxidation of lipids and proteins in cerebral formations in chronic hyperglycemia under the conditions of application of nootropic agents]. Farmakolohiia ta likarska toksykolohiia, 5, 112 –113 (in Ukrainian)
[Жилюк, В., & Мамчур, В. (2011). Активність процесів вільнорадикального окислення ліпідів і білків в утвореннях головного мозку при хронічній гіперглікемії за умов застосування ноотропних засобів. Фармакологія та лікарська токсикологія, 5, 112 –113].


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