A Systematic Review of Global Research on Post Infectious Bronchiolitis Obliterans in Children
Abstract
The article aims to analyse the diagnosis of PIBO, inform readers about prediction models, and explore current therapeutic trends.
The Systematic Review was conducted as per PRISMA reporting guidelines. The search was done from PUBMED, Cochrane Library, Embase, and Google Scholar for relevant recent studies till September 2023. The study was selected for those satisfying the following criteria: 1) Studies include only children with Post- Infectious Bronchiolitis Obliterans; 2) Original articles with cross-sectional, case-control, and RCT were included. The data collected includes the type of study, author, publication year, study period, study design, study country, number of participants, diagnostic criteria of Post-Infectious Bronchiolitis Obliterans, respiratory pathogens, risk factors, and current therapy trends. The first part of the study involves making the entity of Post-Infectious Bronchiolitis Obliterans well understood through the various primary studies. The second part is about medical treatment attempted successfully by multiple professionals and their studies. Studies including Haematopoietic Stem Cell Transplantation, Lung Transplantation, and chronic lung disease were excluded.
With this information, an attempt has been made to simplify the identification of PIBO, avoid misdiagnosis, and shed some light on the various Prediction models for PIBO and the therapies tried with some success.Keywords
Full Text:
PDFReferences
1. Vásquez D, M., Lay-Son R, G., Vial U, F., Boza C, M. L., Contreras E, I., Lozano C, J., Zenteno A, D., & Repetto L, M. G. (2012). Expanding the CFTR mutation spectrum in Chilean patients with cystic fibrosis. Revista Chilena De Enfermedades Respiratorias, 28(2), 99–103.
2. Bandeira, T., Negreiro, F., Ferreira, R., Salgueiro, M., Lobo, L., Aguiar, P., & Trindade, J. C. (2011). Clinical, radiological, and physiological differences between obliterative bronchiolitis and problematic severe asthma in adolescents and young adults: The early origins of the overlap syndrome? Pediatric Pulmonology, 46(6), 573–580. doi: 10.1002/ppul.21405
3. Teper, A. M., Kofman, C. D., Maffey, A. F., & Vidaurreta, S. M. (1999). Lung function in infants with chronic pulmonary disease after severe adenoviral illness. The Journal of Pediatrics, 134(6), 730–733. doi: 10.1016/s0022-3476(99)70289-1
4. Haran Jogeesvaran, K., & Owens, C. M. (2010). Chronic diseases of lung parenchyma in children: the role of imaging. Pediatric Radiology, 40(6), 850–858. doi: 10.1007/s00247-010-1615-9
5. Zhang, L., Irion, K., da Silva Porto, N., & e Silva, F. A. (1999). High-Resolution Computed Tomography in Pediatric Patients With Post-infectious Bronchiolitis Obliterans. Journal of Thoracic Imaging, 14(2), 85–89. doi: 10.1097/00005382-199904000-00003
6. du Plessis, A., Andronikou, S., Machemedze, T., Griffith‐Richards, S., Myer, L., Mahtab, S., & Zar, H. J. (2019). High‐resolution computed tomography features of lung disease in perinatally HIV‐infected adolescents on combined antiretroviral therapy. Pediatric Pulmonology, 54(11), 1765–1773. doi: 10.1002/ppul.24450
7. Castro‐Rodriguez, J. A., Giubergia, V., Fischer, G. B., Castaños, C., Sarria, E. E., Gonzalez, R., Mattiello, R., Vega‐Briceño, L. E., & Murtagh, P. (2014). Post-infectious bronchiolitis obliterans in children: the South American contribution. Acta Paediatrica, 103(9), 913–921. doi: 10.1111/apa.12689
8. Maia, S. A., Eli, D., Cunha, R., Bitencourt, E., Riedi, C. A., Chong Neto, H. J., Silva, D. C. C. e, & Rosário Filho, N. A. (2019). Clinical, functional, and cytological evaluation of sputum in post-infectious bronchiolitis obliterans: a possible overlap with asthma? Jornal Brasileiro de Pneumologia, 45(5). doi: 10.1590/1806-3713/e20190060
9. Zhang, X.-M., Lu, A.-Z., Yang, H.-W., Qian, L.-L., Wang, L.-B., & Zhang, X.-B. (2018). Clinical features of post-infectious bronchiolitis obliterans in children undergoing long-term nebulisation treatment. World Journal of Pediatrics, 14(5), 498–503. doi: 10.1007/s12519-018-0193-z
10. Kim, Y. H., Shin, H. J., Sol, I. S., Kim, S. Y., Kim, J. D., Yoon, H., Kim, K. W., Kim, M.-J., Lee, M.-J., & Sohn, M. H. (2017). Lung Clearance Index and Quantitative Computed Tomography of Post-Infectious Bronchiolitis Obliterans in Infants. Scientific Reports, 7(1). doi: 10.1038/s41598-017-15330-8
11. Mattiello, R., Vidal, P. C., Sarria, E. E., Pitrez, P. M., Stein, R. T., Mocelin, H. T., Fischer, G. B., Jones, M. H., & Pinto, L. A. (2016). Evaluating bronchodilator response in pediatric patients with post-infectious bronchiolitis obliterans: use of different criteria for identifying airway reversibility. Jornal Brasileiro de Pneumologia, 42(3), 174–178. doi: 10.1590/s1806-37562015000000065
12. Zhang, J., Zhu, Y., Zhou, Y., Gao, F., Qiu, X., Li, J., Yuan, H., Jin, W., & Lin, W. (2023). Pediatric adenovirus pneumonia: clinical practice and current treatment. Frontiers in Medicine, 10. doi: 10.3389/fmed.2023.1207568
13. Teper, A., Colom, A. J., Schubert, R., & Jerkic, P. (2023). Update in post-infectious bronchiolitis obliterans. Pediatric Pulmonology. doi: 10.1002/ppul.26570
14. Behrendt, A., & Lee, Y. (2023, May 1). Swyer-James-MacLeod Syndrome. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK554442/
15. Pandey, S. (2023). Comment on "Post-infectious bronchiolitis obliterans in children: Clinical and radiological evaluation and long-term results." Heart & Lung, 58, 254–255. doi: 10.1016/j.hrtlng.2022.09.013
16. Lee, E., Park, S., & Yang, H.-J. (2022). Pulmonary Function in Post-Infectious Bronchiolitis Obliterans in Children: A Systematic Review and Meta-Analysis. Pathogens, 11(12), 1538. doi: 10.3390/pathogens11121538
17. Kang, M., Ahn, H., Lee, S., Yeom, J., Kim, K., & Hong, S. (2022). TGFβ1 and POSTN as biomarkers of post-infectious bronchiolitis obliterans and asthma in children. Pediatric Pulmonology, 57(12), 3161–3164. doi: 10.1002/ppul.26139
18. Zhang, D., Chen, Y., Shi, T., Fan, H., Tian, X., Zhou, R., Huang, L., Yang, D., & Lu, G. (2022). Severe pneumonia caused by human adenovirus type 55 in children. Frontiers in Pediatrics, 10. doi: 10.3389/fped.2022.1002052
19. Lee, E., & Choi, I. (2022). Clinical Usefulness of Serum Lactate Dehydrogenase Levels in Mycoplasma pneumoniae Pneumonia in Children. Indian Journal of Pediatrics, 89(10), 1003–1009. doi: 10.1007/s12098-022-04205-0
20. Flanagan, F., Casey, A., Reyes-Múgica, M., & Kurland, G. (2022). Post-infectious bronchiolitis obliterans in children. Paediatric Respiratory Reviews, 42, 69–78. doi: 10.1016/j.prrv.2022.01.007
21. Yu, X., Ma, Y., Gao, Y., & You, H. (2021). Epidemiology of Adenovirus Pneumonia and Risk Factors for Bronchiolitis Obliterans in Children During an Outbreak in Jilin, China. Frontiers in Pediatrics, 9. doi: 10.3389/fped.2021.722885
22. Jerkic, S. P., Koc‐Günel, S., Herrmann, E., Kriszeleit, L., Eckrich, J., Schubert, R., & Zielen, S. (2021). Long‐term course of bronchial inflammation and pulmonary function testing in children with post-infectious bronchiolitis obliterans. Pediatric Pulmonology, 56(9), 2966–2972. Portico. doi: 10.1002/ppul.25547
23. Yazan, H., Khalif, F., Shadfaan, L. A., Bilgin, S., Nursoy, M., Cakir, F. B., Cakin, Z. E., Uzuner, S., & Cakir, E. (2021). Post-infectious bronchiolitis obliterans in children: Clinical and radiological evaluation and long-term results. Heart & Lung, 50(5), 660–666. doi: 10.1016/j.hrtlng.2021.05.001
24. Jimenez, A., & De Jesús-Rojas, W. (2021). Mycoplasma pneumoniae and Bronchiolitis Obliterans: How a Common Organism Leads to a Rare Pulmonary Disease in Pediatrics. Cureus. doi: 10.7759/cureus.17193
25. Weng, T., Lin, X., Wang, L., Lv, J., & Dong, L. (2021). Follow-up on the therapeutic effects of a budesonide, azithromycin, montelukast, and acetylcysteine (BAMA) regimen in children with post-infectious bronchiolitis obliterans. Journal of Thoracic Disease, 13(8), 4775–4784. doi: 10.21037/jtd-20-3195
26. Fujita, Y., Miyamoto, K., Imataka, G., & Yoshihara, S. (2021). Post-infectious Bronchiolitis Obliterans Misdiagnosed as Bronchial Asthma in a Pediatric Patient. The Tohoku Journal of Experimental Medicine, 254(4), 257–260. doi: 10.1620/tjem.254.257
27. Lee, E., & Young Lee, Y. (2020). Risk factors for the development of post-infectious bronchiolitis obliterans after Mycoplasma pneumoniae pneumonia in the era of increasing macrolide resistance. Respiratory Medicine, 175, 106209. doi: 10.1016/j.rmed.2020.106209
28. Chen, X., Shu, J., Huang, Y., Long, Z., & Zhou, X. (2020). Therapeutic effect of budesonide, montelukast and azithromycin on post‑infectious bronchiolitis obliterans in children. Experimental and Therapeutic Medicine. doi: 10.3892/etm.2020.8983
29. Jerkic, S.-P., Brinkmann, F., Calder, A., Casey, A., Dishop, M., Griese, M., Kurland, G., Niemitz, M., Nyilas, S., Schramm, D., Schubert, R., Tamm, M., Zielen, S., & Rosewich, M. (2020). Post-infectious Bronchiolitis Obliterans in Children: Diagnostic Workup and Therapeutic Options: A Workshop Report. Canadian Respiratory Journal, 2020, 1–16. doi: 10.1155/2020/5852827
30. Kavaliunaite, E., & Aurora, P. (2019). Diagnosing and managing bronchiolitis obliterans in children. Expert Review of Respiratory Medicine, 13(5), 481–488. doi: 10.1080/17476348.2019.1586537
31. Kim, J., Kim, M.-J., Sol, I. S., Sohn, M. H., Yoon, H., Shin, H. J., Kim, K. W., & Lee, M.-J. (2019). Quantitative CT and pulmonary function in children with post-infectious bronchiolitis obliterans. PLOS ONE, 14(4), e0214647. doi: 10.1371/journal.pone.0214647
32. Rodrigues, C. M. B., Schiwe, D., Campos, N. E. de, Niederauer, F., & Heinzmann-Filho, J. P. (2019). Exercise Capacity In Children And Adolescents With Post-Infectious Bronchiolitis Obliterans: A Systematic Review. Revista Paulista de Pediatria, 37(2), 234–240. doi: 10.1590/1984-0462/;2019;37;2;00017
33. Xie, B.-Q., Wang, W., Zhang, W.-Q., Guo, X.-H., Yang, M.-F., Wang, L., He, Z.-X., & Tian, Y.-Q. (2014). Ventilation/Perfusion Scintigraphy in Children with Post-Infectious Bronchiolitis Obliterans: A Pilot Study. PLoS ONE, 9(5), e98381. doi: 10.1371/journal.pone.0098381
34. Yoon, H. M., Lee, J. S., Hwang, J.-Y., Cho, Y. A., Yoon, H.-K., Yu, J., Hong, S.-J., & Yoon, C. H. (2015). Post-infectious bronchiolitis obliterans in children: CT features that predict responsiveness to pulse methylprednisolone. The British Journal of Radiology, 88(1049), 20140478. doi: 10.1259/bjr.20140478
35. Yu, J. (2015). Post-infectious bronchiolitis obliterans in children: lessons from bronchiolitis obliterans after lung transplantation and hematopoietic stem cell transplantation. Korean Journal of Pediatrics, 58(12), 459. doi: 10.3345/kjp.2015.58.12.459
36. Tanou, K., Xaidara, A., & Kaditis, A. G. (2015). Efficacy of pulse methylprednisolone in a pediatric case of postinfectious bronchiolitis obliterans. Pediatric Pulmonology, 50(5), E13–E16. doi: https://doi.org/10.1002/ppul.23157
37. Mattiello, R., Mallol, J., Fischer, G. B., Mocelin, H. T., Rueda, B., & Sarria, E. E. (2010). Função pulmonar de crianças e adolescentes com bronquiolite obliterante pós-infecciosa. Jornal Brasileiro de Pneumologia, 36(4), 453–459. doi: 10.1590/s1806-37132010000400010
38. Kearns, G. L., Lu, S., Maganti, L., Li, X. (Susie), Migoya, E., Ahmed, T., Knorr, B., & Reiss, T. F. (2008). Pharmacokinetics and Safety of Montelukast Oral Granules in Children 1 to 3 Months of Age With Bronchiolitis. The Journal of Clinical Pharmacology, 48(4), 502–511. doi: https://doi.org/10.1177/0091270008314251
39. Yalçın, E., Doğru, D., Haliloğlu, M., Özçelik, U., Kiper, N., & Göçmen, A. (2003). Postinfectious Bronchiolitis obliterans in Children: Clinical and Radiological Profile and Prognostic Factors. Respiration, 70(4), 371–375. doi: 10.1159/000072900
40. Zhang, L., & Silva, F. A. e. (2000). Bronchiolitis obliterans in children. Jornal de Pediatria, 76(3), 185–192. doi: 10.2223/jped.49
41. Yan, S., Sun, C., & Jiang, K. (2023). A Diagnostic Nomogram for Early Prediction of Post-Infectious Bronchiolitis Obliterans in Severe Pneumonia. Journal of Inflammation Research, 16, 2041–2050. doi: 10.2147/jir.s406375
42. Bisgaard, H., Flores-Nunez, A., Goh, A., Azimi, P., Halkas, A., Malice, M.-P., Marchal, J.-L., Dass, S. B., Reiss, T. F., & Knorr, B. A. (2008). Study of Montelukast for the Treatment of Respiratory Symptoms of Post–Respiratory Syncytial Virus Bronchiolitis in Children. American Journal of Respiratory and Critical Care Medicine, 178(8), 854–860. doi: 10.1164/rccm.200706-910oc
43. Onay, Z. R., Ramasli Gursoy, T., Aslan, A. T., Sismanlar Eyuboglu, T., Kibar, B. S., Pekcan, S., Hangul, M., Kose, M., Budakoglu, I. I., & Gokturk, B. (2020). Post-infectious bronchiolitis obliterans masked by misdiagnosis as asthma. Pediatric Pulmonology, 55(4), 1007–1011. doi: 10.1002/ppul.24690
44. Peng, L., Liu, S., Xie, T., Li, Y., Yang, Z., Chen, Y., Deng, L., Huang, H., Ding, X., Chen, M., Lin, L., Wei, S., & Zhong, L. (2023). Construction and analysis of a nomogram prediction model for post-infectious bronchiolitis obliterans in children with adenovirus pneumonia after invasive mechanical ventilation. BMC Pediatrics, 23(1). doi: 10.1186/s12887-023-03883-9
45. Manganotti, P., Garascia, G., Furlanis, G., & Buoite Stella, A. (2023). Efficacy of intravenous immunoglobulin (IVIg) on COVID-19-related neurological disorders over the last 2 years: an up-to-date narrative review. Frontiers in Neuroscience, 17. doi: 10.3389/fnins.2023.1159929
44. Lee, E., Park, S., Kim, K., & Yang, H.-J. (2022). Risk Factors for the Development of Post-Infectious Bronchiolitis Obliterans in Children: A Systematic Review and Meta-Analysis. Pathogens, 11(11), 1268. doi: 10.3390/pathogens11111268
45. Zheng, H., Yu, X., Chen, Y., Lin, W., & Liu, L. (2022). Effects of Inhaled Corticosteroids on Lung Function in Children With Post-infectious Bronchiolitis Obliterans in Remission. Frontiers in Pediatrics, 10. doi: 10.3389/fped.2022.827508
46. Jung, J. H., Kim, G. E., Min, I. K., Jang, H., Kim, S. Y., Kim, M. J., Kim, Y. H., Shin, H. J., Yoon, H., Sohn, M. H., Lee, M., & Kim, K. W. (2020). Prediction of post-infectious bronchiolitis obliterans prognosis in children. Pediatric Pulmonology, 56(5), 1069–1076. doi: 10.1002/ppul.25220
47. Yu, X., Wei, J., Li, Y., Zhang, L., Che, H., & Liu, L. (2021). Longitudinal Assessment of Pulmonary Function and Bronchodilator Response in Pediatric Patients With Post-infectious Bronchiolitis Obliterans. Frontiers in Pediatrics, 9. doi: 10.3389/fped.2021.674310
48. Li, Y.-N., Huang, F., Ma, Y.-C., & Wang, F. (2021). Clinical analysis of adenovirus post-infectious bronchiolitis obliterans and nonadenovirus post-infectious bronchiolitis obliterans in children. Lung India, 38(2), 117. doi: 10.4103/lungindia.lungindia_374_20
49. Jat, K., Gulla, K., Lodha, R., & Kabra, S. (2020). Clinical profile and course of children with post-infectious bronchiolitis obliterans from a tertiary care hospital. Lung India, 37(1), 8. doi: 10.4103/lungindia.lungindia_145_19
50. Onay, Z. R., Ramasli Gursoy, T., Aslan, A. T., Sismanlar Eyuboglu, T., Kibar, B. S., Pekcan, S., Hangul, M., Kose, M., Budakoglu, I. I., & Gokturk, B. (2020). Post-infectious bronchiolitis obliterans masked by misdiagnosis as asthma. Pediatric Pulmonology, 55(4), 1007–1011. doi: 10.1002/ppul.24690
51. Chen, I.-C., Hsu, J.-S., Chen, Y.-W., Liu, Y.-C., Wu, Y.-H., Hsu, J.-H., Cheng, Y.-F., & Dai, Z.-K. (2020). Post-infectious Bronchiolitis Obliterans: HRCT, DECT, Pulmonary Scintigraphy Images, and Clinical Follow-up in Eight Children. Frontiers in Pediatrics, 8. doi: 10.3389/fped.2020.622065
52. Rosewich, M., Zissler, U. M., Kheiri, T., Voss, S., Eickmeier, O., Schulze, J., Herrmann, E., Dücker, R. P., Schubert, R., & Zielen, S. (2015). Airway inflammation in children and adolescents with bronchiolitis obliterans. Cytokine, 73(1), 156–162. doi: 10.1016/j.cyto.2014.10.026
53. Moonnumakal, S. P., & Fan, L. L. (2008). Bronchiolitis obliterans in children. Current Opinion in Pediatrics, 20(3), 272–278. doi: 10.1097/mop.0b013e3282ff62e9
54. Weng, T., Lin, X., Wang, L., Lv, J., & Dong, L. (2021). Follow-up on the therapeutic effects of a budesonide, azithromycin, montelukast, and acetylcysteine (BAMA) regimen in children with post-infectious bronchiolitis obliterans. Journal of Thoracic Disease, 13(8), 4775–4784. doi: 10.21037/jtd-20-3195
55. Abtahi, H., Peiman, S., Foroumandi, M., & Safavi, E. (2016). Long Term Follow-Up of Sulfur Mustard Related Bronchiolitis Obliterans Treatment. Acta medica Iranica, 54(9), 605–609.
56. Yilmaz, A. İ., Gül, Y., Kapaklı, H., Ünal, G., Çağlar, H. T., Ercan, F., Reisli, İ., Keleş, S., Poyraz, N., & Pekcan, S. (2023). Successful treatment of post-infectious bronchiolitis obliterans with gamma globulin in a tertiary center: 10 years of experience. Pediatric Pulmonology, 58(10), 2769–2776. doi: 10.1002/ppul.26577
57. Duecker, R. P., De Mir Messa, I., Jerkic, S., Kochems, A., Gottwald, G., Moreno‐Galdó, A., Rosewich, M., Gronau, L., Zielen, S., Geburtig‐Chiocchetti, A., Kreyenberg, H., & Schubert, R. (2022). Epigenetic regulation of inflammation by microRNAs in post‐infectious bronchiolitis obliterans. Clinical & Translational Immunology, 11(2). doi: 10.1002/cti2.1376
Article Metrics
Metrics powered by PLOS ALM
Refbacks
- There are currently no refbacks.
Copyright (c) 2024 Vasanta Sengupta, Abhijit Sengupta
This work is licensed under a Creative Commons Attribution 4.0 International License.
Email the author