Molecularly Imprinted Polymer-Based Electrochemical Sensing in Protein Detection

Pedro da Fonseca Soares Rodrigues, Paulo Fernando Guimarães Morando Marzocchi Tierno, Gustavo Augusto Couto Carvalho, João Marcos Moreira Guimarães Santos

Abstract

Protein detection is paramount across various scientific, clinical, and industrial domains. Accurate and sensitive detection of proteins is pivotal for understanding biological processes, diagnosing diseases, drug development, environmental monitoring, and ensuring food safety. Traditional protein detection methods encounter sensitivity, specificity, and ease of use challenges. Molecularly imprinted polymers (MIPs), with their tailored molecular recognition sites, offer a novel approach to address these limitations. When combined with electrochemical techniques, MIP-based electrochemical methods have emerged as a revolutionary technology, showcasing enhanced sensitivity and selectivity. This article provides a comprehensive overview of MIP-based electrochemical methods for protein detection, including the principles, engineering aspects, advantages, and potential applications. The aim is to elucidate the potential of this cutting-edge technology in reshaping protein detection and its promising role in advancing biosensing technologies.

10.22178/pos.96-7


Keywords


proteins; biomolecular recognition; analytical methods; sensitivity; specificity

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References


1. Antipchik, M., Reut, J., Ayankojo, A. G., Öpik, A., & Syritski, V. (2022). MIP-based electrochemical sensor for direct detection of hepatitis C virus via E2 envelope protein. Talanta, 250, 123737. doi: 10.1016/j.talanta.2022.123737

2. Bueno, L., El-Sharif, H. F., Salles, M. O., Boehm, R. D., Narayan, R. J., Paixão, T. R. L. C., & Reddy, S. M. (2014). MIP-based electrochemical protein profiling. Sensors and Actuators B: Chemical, 204, 88–95. doi: 10.1016/j.snb.2014.07.100

3. Mazouz, Z., Mokni, M., Fourati, N., Zerrouki, C., Barbault, F., Seydou, M., Kalfat, R., Yaakoubi, N., Omezzine, A., Bouslema, A., & Othmane, A. (2020). Computational approach and electrochemical measurements for protein detection with MIP-based sensor. Biosensors and Bioelectronics, 151, 111978. doi: 10.1016/j.bios.2019.111978

4. Di Giulio, T., Mazzotta, E., & Malitesta, C. (2020). Molecularly Imprinted Polyscopoletin for the Electrochemical Detection of the Chronic Disease Marker Lysozyme. Biosensors, 11(1), 3. doi: 10.3390/bios11010003

5. Ratautaite, V., Boguzaite, R., Brazys, E., Ramanaviciene, A., Ciplys, E., Juozapaitis, M., Slibinskas, R., Bechelany, M., & Ramanavicius, A. (2022). Molecularly imprinted polypyrrole based sensor for the detection of SARS-CoV-2 spike glycoprotein. Electrochimica Acta, 403, 139581. doi: 10.1016/j.electacta.2021.139581

6. Mazzotta, E., Di Giulio, T., & Malitesta, C. (2022). Electrochemical sensing of macromolecules based on molecularly imprinted polymers: challenges, successful strategies, and opportunities. Analytical and Bioanalytical Chemistry, 414(18), 5165–5200. doi: 10.1007/s00216-022-03981-0

7. Thomaz, D. V., Goldoni, R., Tartaglia, G. M., Malitesta, C., & Mazzotta, E. (2022). Effect of Recombinant Antibodies and MIP Nanoparticles on the Electrical Behavior of Impedimetric Biorecognition Surfaces for SARS-CoV-2 Spike Glycoprotein: A Short Report. Electrochem, 3(3), 538–548. doi: 10.3390/electrochem3030037

8. Liu, Y., & Dykstra, G. (2022). Recent progress on electrochemical (bio)sensors based on aptamer-molecularly imprinted polymer dual recognition. Sensors and Actuators Reports, 4, 100112. doi: 10.1016/j.snr.2022.100112

9. Ben Hassine, A., Raouafi, N., & Moreira, F. T. C. (2021). Novel Electrochemical Molecularly Imprinted Polymer-Based Biosensor for Tau Protein Detection. Chemosensors, 9(9), 238. doi: 10.3390/chemosensors9090238

10. Choi, D. Y., Yang, J. C., Hong, S. W., & Park, J. (2022). Molecularly imprinted polymer-based electrochemical impedimetric sensors on screen-printed carbon electrodes for the detection of trace cytokine IL-1β. Biosensors and Bioelectronics, 204, 114073. doi: 10.1016/j.bios.2022.114073

11. Lee, M.-H., Thomas, J. L., Chang, Y.-C., Tsai, Y.-S., Liu, B.-D., & Lin, H.-Y. (2016). Electrochemical sensing of nuclear matrix protein 22 in urine with molecularly imprinted poly(ethylene-co-vinyl alcohol) coated zinc oxide nanorod arrays for clinical studies of bladder cancer diagnosis. Biosensors and Bioelectronics, 79, 789–795. doi: 10.1016/j.bios.2016.01.005

12. Pacheco, J. G., Silva, M. S. V., Freitas, M., Nouws, H. P. A., & Delerue-Matos, C. (2018). Molecularly imprinted electrochemical sensor for the point-of-care detection of a breast cancer biomarker (CA 15-3). Sensors and Actuators B: Chemical, 256, 905–912. doi: 10.1016/j.snb.2017.10.027

13. Zidarič, T., Finšgar, M., Maver, U., & Maver, T. (2022). Artificial Biomimetic Electrochemical Assemblies. Biosensors, 12(1), 44. doi: 10.3390/bios12010044

14. Hasseb, A. A., Abdel Ghani, N. din T., Shehab, O. R., & El Nashar, R. M. (2022). Application of molecularly imprinted polymers for electrochemical detection of some important biomedical markers and pathogens. Current Opinion in Electrochemistry, 31, 100848. doi: 10.1016/j.coelec.2021.100848

15. Li, R., Feng, Y., Pan, G., & Liu, L. (2019). Advances in Molecularly Imprinting Technology for Bioanalytical Applications. Sensors, 19(1), 177. doi: 10.3390/s19010177

16. Dykstra, G., Reynolds, B., Smith, R., Zhou, K., & Liu, Y. (2022). Electropolymerized Molecularly Imprinted Polymer Synthesis Guided by an Integrated Data-Driven Framework for Cortisol Detection. ACS Applied Materials & Interfaces, 14(22), 25972–25983. doi: 10.1021/acsami.2c02474

17. Meskher, H., Ragdi, T., Thakur, A. K., Ha, S., Khelfaoui, I., Sathyamurthy, R., Sharshir, S. W., Pandey, A. K., Saidur, R., Singh, P., Sharifian jazi, F., & Lynch, I. (2023). A Review on CNTs-Based Electrochemical Sensors and Biosensors: Unique Properties and Potential Applications. Critical Reviews in Analytical Chemistry, 1–24. doi: 10.1080/10408347.2023.2171277

18. Brambilla, E., Locarno, S., Gallo, S., Orsini, F., Pini, C., Farronato, M., Thomaz, D. V., Lenardi, C., Piazzoni, M., & Tartaglia, G. (2022). Poloxamer-Based Hydrogel as Drug Delivery System: How Polymeric Excipients Influence the Chemical-Physical Properties. Polymers, 14(17), 3624. doi: 10.3390/polym14173624

19. Goldoni, R., Thomaz, D. V., Di Giulio, T., Malitesta, C., & Mazzotta, E. (2022). An insight into polyscopoletin electrosynthesis by a quality-by-design approach. Journal of Materials Science, 57(25), 12161–12175. doi: 10.1007/s10853-022-07349-8

20. Rajpal, S., & Mishra, P. (2022). Next generation biosensors employing molecularly imprinted polymers as sensing elements for in vitro diagnostics. Biosensors and Bioelectronics: X, 11, 100201. doi: 10.1016/j.biosx.2022.100201

21. Li, Y., Luo, L., Nie, M., Davenport, A., Li, Y., Li, B., & Choy, K.-L. (2022). A graphene nanoplatelet-polydopamine molecularly imprinted biosensor for Ultratrace creatinine detection. Biosensors and Bioelectronics, 216, 114638. doi: 10.1016/j.bios.2022.114638

22. Zhang, J., Wang, Y., & Lu, X. (2021). Molecular imprinting technology for sensing foodborne pathogenic bacteria. Analytical and Bioanalytical Chemistry, 413(18), 4581–4598. doi: 10.1007/s00216-020-03138-x

23. Lu, Z., Du, X., Sun, M., Zhang, Y., Li, Y., Wang, X., Wang, Y., Du, H., Yin, H., & Rao, H. (2021). Novel dual-template molecular imprinted electrochemical sensor for simultaneous detection of CA and TPH based on peanut twin-like NiFe2O4/CoFe2O4/NCDs nanospheres: Fabrication, application and DFT theoretical study. Biosensors and Bioelectronics, 190, 113408. doi: 10.1016/j.bios.2021.113408

24. Shao, Y., Duan, J., Wang, M., Cao, J., She, Y., Cao, Z., Li, G., Jin, F., Wang, J., & Abd El-Aty, A. M. (2022). Application of Molecularly Imprinted Electrochemical Biomimetic Sensors for Detecting Small Molecule Food Contaminants. Polymers, 15(1), 187. doi: 10.3390/polym15010187

25. Li, W., Zhang, X., Li, T., Ji, Y., & Li, R. (2021). Molecularly imprinted polymer-enhanced biomimetic paper-based analytical devices: A review. Analytica Chimica Acta, 1148, 238196. doi: 10.1016/j.aca.2020.12.071

26. Thomaz, D. V., Couto, R. O., de Oliveira Roberth, A., Oliveira, L. A. R., de Siqueira Leite, K. C., de Freitas Bara, M. T., Ghedini, P. C., Bozinis, M. C. V., Lobón, G. S., de Souza Gil, E., & Machado, F. B. (2018). Assessment of Noni (Morinda citrifolia L.) Product Authenticity by Solid State Voltammetry. International Journal of Electrochemical Science, 13(9), 8983–8994. doi: 10.20964/2018.09.390

27. Macêdo, I. Y. L. de, Alecrim, M. F., Oliveira Neto, J. R., Torres, I. M. S., Thomaz, D. V., & Gil, E. de S. (2020). Piroxicam voltammetric determination by ultra low cost pencil graphite electrode. Brazilian Journal of Pharmaceutical Sciences, 56. doi: 10.1590/s2175-97902019000317344

28. Goldoni, R., Thomaz, D. V., Strambini, L., Tumedei, M., Dongiovanni, P., Isola, G., & Tartaglia, G. (2023). Quality-by-Design R&D of a Novel Nanozyme-Based Sensor for Saliva Antioxidant Capacity Evaluation. Antioxidants, 12(5), 1120. doi: 10.3390/antiox12051120

29. Dongiovanni, P., Meroni, M., Casati, S., Goldoni, R., Thomaz, D. V., Kehr, N. S., Galimberti, D., Del Fabbro, M., & Tartaglia, G. M. (2023). Salivary biomarkers: novel noninvasive tools to diagnose chronic inflammation. International Journal of Oral Science, 15(1). doi: 10.1038/s41368-023-00231-6

30. Contardi, U. A., Morikawa, M., Brunelli, B., & Thomaz, D. V. (2021). MAX30102 Photometric Biosensor Coupled to ESP32-Webserver Capabilities for Continuous Point of Care Oxygen Saturation and Heartrate Monitoring. The 2nd International Electronic Conference on Biosensors. doi: 10.3390/iecb2022-11114

31. Ferraz, D., Thomaz, D. V., Antunes, R. S., & Lopes, F. M. (2021). Development of a low-cost colorimetric paper-based spot test for the environmental monitoring of phenolic pollutants. Environmental Challenges, 4, 100128. doi: 10.1016/j.envc.2021.100128

32. Thomaz, D. V., de Oliveira, M. T., Lobón, G. S., da Cunha, C. E. P., Machado, F. B., Moreno, E. K. G., de Siqueira Leite, K. C., Ballaminut, N., Alecrim, M. F., de Carvalho, M. F., Isecke, B. G., de Macêdo, I. Y. L., do Couto, R. O., Rodrigues, E. S. B., de Faria Carvalho, L. A., & Ávila, L. F. (2018). Development of Laccase-TiO2@Carbon Paste Biosensor for Voltammetric Determination of Paracetamol. International Journal of Electrochemical Science, 13(11), 10884–10893. doi: 10.20964/2018.11.61

33. Lima Morais, R., Ferreira Garcia, L., Kussmaul Gonçalves Moreno, E., Vieira Thomaz, D., De Brito Rodrigues, L., Barroso Brito, L., Sanz Lobón, G., Augusto Rodrigues de Oliveira, G., Ferreira Rodrigues, M., Gontijo Vaz, B., & Gil, E. D. S. (2019). Electrochemical remediation of industrial pharmaceutical wastewater containing hormones in a pilot scale treatment system. Eclética Química Journal, 44(1), 40. doi: 10.26850/1678-4618eqj.v44.1.2019.p40-52

34. Garcia, L. F., Lacerda, M. F. A. R., Thomaz, D. V., de Souza Golveia, J. C., Pereira, M. das G. C., de Souza Gil, E., Schimidt, F., & Santiago, M. F. (2019). Optimization of laccase–alginate–chitosan-based matrix toward 17 α-ethinylestradiol removal. Preparative Biochemistry and Biotechnology, 49(4), 375–383. doi: 10.1080/10826068.2019.1573195

35. Morais, R. L., Garcia, L. F., Thomaz, D. V., Lobón, G. S., Rodrigues, M. F., Vaz, B. G., Caetano, M. P., de Lacerda Medrado, L. C., Nunes, E. S., dos Santos, C. G., Ávila, L. F., de Souza, K. M., Vieira, R. P., & de Souza Gil, E. (2019). Electrochemical Removal of Algestone Acetophenide and Estradiol Enanthate in Real Industrial Wastewater. International Journal of Electrochemical Science, 14(6), 5856–5867. doi: 10.20964/2019.04.42

36. Lacerda, M. F. A. R., Lopes, F. M., Sartoratto, A., Ponezi, A. N., Thomaz, D. V., Schimidt, F., & Santiago, M. F. (2018). Stability of immobilized laccase on Luffa Cylindrica fibers and assessment of synthetic hormone degradation. Preparative Biochemistry and Biotechnology, 49(1), 58–63. doi: 10.1080/10826068.2018.1525568

37. Golveia, J. C. S., Santiago, M. F., Sales, P. T. F., Sartoratto, A., Ponezi, A. N., Thomaz, D. V., Gil, E. de S., & F. Bara, M. T. (2018). Cupuaçu (Theobroma grandiflorum) residue and its potential application in the bioremediation of 17-Α-ethinylestradiol as a Pycnoporus sanguineus laccase inducer. Preparative Biochemistry & Biotechnology, 48(6), 541–548. doi: 10.1080/10826068.2018.1466161

38. Coelho, G. D., Silva, K. K. S., Silva, D. P. D., Soares, J. K. N. C., Ballaminut, N., & Thomaz, D. V. (2020). Biodegradation of Synthetic Effluent Containing CI Direct Red 28 (Congo Red) by Lentinus sp. Laccase Leads to Low Ecotoxicity. Current Biotechnology, 9(2), 127–133. doi: 10.2174/2211550109999200720162021

39. Coelho, G. D., Ballaminut, N., Thomaz, D. V., & Gomes Machado, K. M. (2019). Characterization of a thermostable Deconica castanella Laccase and application toward pentachlorophenol degradation. Preparative Biochemistry & Biotechnology, 49(9), 908–915. doi: 10.1080/10826068.2019.1636280

40. Silva, M. A., Nascimento Júnior, J. C. do, Thomaz, D. V., Maia, R. T., Costa Amador, V., Tommaso, G., & Coelho, G. D. (2022). Comparative homology of Pleurotus ostreatus laccase enzyme: Swiss model or Modeller? Journal of Biomolecular Structure and Dynamics, 41(18), 8927–8940. doi: 10.1080/07391102.2022.2138975

41. Neto, S. L. M., Coelho, G. D., Ballaminut, N., Matheus, D. R., Thomaz, D. V., & Machado, K. M. G. (2021). Application of Deconica castanella ligninolytic enzymatic system in the degradation of hexachlorobenzene in soil. Biotechnology and Applied Biochemistry, 69(6), 2437–2444. doi: 10.1002/bab.2293

42. Vieira Thomaz, D. (2021). Thermodynamics and Kinetics of Camellia sinensis Extracts and Constituents: An Untamed Antioxidant Potential. Bioactive Compounds in Nutraceutical and Functional Food for Good Human Health. doi: 10.5772/intechopen.92813

43. Alves, C. B., Rodrigues, E. S. B., Thomaz, D. V., Aguiar Filho, A. M. de, Gil, E. de S., & Couto, R. O. do. (2020). Correlation of polyphenol content and antioxidant capacity of selected teas and tisanes from Brazilian market. Brazilian Journal of Food Technology, 23. doi: 10.1590/1981-6723.03620

44. Batista, R. D., de Cássia Sousa Mendes, D., Morais, C. C., Thomaz, D. V., Ramirez Ascheri, D. P., Damiani, C., & Asquieri, E. R. (2020). Physicochemical, functional and rheological properties of fermented and non-fermented starch from canary seed (Phalaris canariensis). Food Hydrocolloids, 99, 105346. doi: 10.1016/j.foodhyd.2019.105346

45. Moreno, E. K. G., Thomaz, D. V., Machado, F. B., Leite, K. C. S., Rodrigues, E. S. B., Fernandes, M. A., Carvalho, M. F., de Oliveira, M. T., Caetano, M. P., da Cunha Peixoto, C. E., Isecke, B. G., de Souza Gil, E., & de Macêdo, I. Y. L. (2019). Antioxidant Study and Electroanalytical Investigation of Selected Herbal Samples Used in Folk Medicine. International Journal of Electrochemical Science, 14(1), 838–847. doi: 10.20964/2019.01.82

46. Leite, K. C. de S., Garcia, L. F., Lobón, G. S., Thomaz, D. V., Moreno, E. K. G., Carvalho, M. F. de, Rocha, M. L., Santos, W. T. P. dos, & Gil, E. de S. (2018). Antioxidant activity evaluation of dried herbal extracts: an electroanalytical approach. Revista Brasileira de Farmacognosia, 28(3), 325–332. doi: 10.1016/j.bjp.2018.04.004

47. Thomaz, D. V., Peixoto, L. F., de Oliveira, T. S., Fajemiroye, J. O., da Silva Neri, H. F., Xavier, C. H., Costa, E. A., dos Santos, F. C. A., de Souza Gil, E., & Ghedini, P. C. (2018). Antioxidant and Neuroprotective Properties of Eugenia dysentericaLeaves. Oxidative Medicine and Cellular Longevity, 2018, 1–9. Doi: 10.1155/2018/3250908

48. de Oliveira, T. S., Thomaz, D. V., da Silva Neri, H. F., Cerqueira, L. B., Garcia, L. F., Gil, H. P. V., Pontarolo, R., Campos, F. R., Costa, E. A., dos Santos, F. C. A., de Souza Gil, E., & Ghedini, P. C. (2018). Neuroprotective Effect of Caryocar brasiliense Camb. Leaves Is Associated with Anticholinesterase and Antioxidant Properties. Oxidative Medicine and Cellular Longevity, 2018, 1–12. doi: 10.1155/2018/9842908

49. Thomaz, D. V., do Couto, R. O., Goldoni, R., Malitesta, C., Mazzotta, E., & Tartaglia, G. M. (2022). Redox Profiling of Selected Apulian Red Wines in a Single Minute. Antioxidants, 11(5), 859. doi: 10.3390/antiox11050859

50. Garcia, L. F., da Cunha, C. E. P., Moreno, E. K. G., Vieira Thomaz, D., Lobón, G. S., Luque, R., Somerset, V., & de Souza Gil, E. (2018). Nanostructured TiO2 Carbon Paste Based Sensor for Determination of Methyldopa. Pharmaceuticals, 11(4), 99. doi: 10.3390/ph11040099

51. da Cunha, C. E. P., Rodrigues, E. S. B., Fernandes Alecrim, M., Thomaz, D. V., Macêdo, I. Y. L., Garcia, L. F., de Oliveira Neto, J. R., Moreno, E. K. G., Ballaminut, N., & de Souza Gil, E. (2019). Voltammetric Evaluation of Diclofenac Tablets Samples through Carbon Black-Based Electrodes. Pharmaceuticals, 12(2), 83. doi: 10.3390/ph12020083

52. Antunes, R. S., Thomaz, D. V., Garcia, L. F., Gil, E. de S., & Lopes, F. M. (2020). Development and Optimization of Solanum Lycocarpum Polyphenol Oxidase-Based Biosensor and Application towards Paracetamol Detection. Advanced Pharmaceutical Bulletin, 11(3), 469–476. doi: 10.34172/apb.2021.054

53. Moreira, L. K. da S., Turones, L. C., Campos, H. M., Nazareth, A. M., Thomaz, D. V., Gil, E. de S., Ghedini, P. C., Rocha, F. F. da, Menegatti, R., Fajemiroye, J. O., & Costa, E. A. (2023). LQFM212, a piperazine derivative, exhibits potential antioxidant effect as well as ameliorates LPS-induced behavioral, inflammatory and oxidative changes. Life Sciences, 312, 121199. doi: 10.1016/j.lfs.2022.121199

54. Moreira, L. K. da S., Silva, R. R., da Silva, D. M., Mendes, M. A. S., de Brito, A. F., de Carvalho, F. S., Sanz, G., Rodrigues, M. F., da Silva, A. C. G., Thomaz, D. V., de Oliveira, V., Vaz, B. G., Lião, L. M., Valadares, M. C., Gil, E. de S., Costa, E. A., Noël, F., & Menegatti, R. (2022). Anxiolytic- and antidepressant-like effects of new phenylpiperazine derivative LQFM005 and its hydroxylated metabolite in mice. Behavioural Brain Research, 417, 113582. doi: 10.1016/j.bbr.2021.113582

55. Thomaz, D. V., de Oliveira, M. G., Rodrigues, E. S. B., da Silva, V. B., & dos Santos, P. A. (2020). Physicochemical Investigation of Psoralen Binding to Double Stranded DNA through Electroanalytical and Cheminformatic Approaches. Pharmaceuticals, 13(6), 108. doi: 10.3390/ph13060108

56. Murdaya, N., Triadenda, A. L., Rahayu, D., & Hasanah, A. N. (2022). A Review: Using Multiple Templates for Molecular Imprinted Polymer: Is It Good? Polymers, 14(20), 4441. doi: 10.3390/polym14204441

57. Furtado, A. I., Viveiros, R., & Casimiro, T. (2021). MIP Synthesis and Processing Using Supercritical Fluids. Methods in Molecular Biology, 19–42. doi: 10.1007/978-1-0716-1629-1_3

58. Lowdon, J. W., Diliën, H., Singla, P., Peeters, M., Cleij, T. J., van Grinsven, B., & Eersels, K. (2020). MIPs for commercial application in low-cost sensors and assays – An overview of the current status quo. Sensors and Actuators B: Chemical, 325, 128973. doi: 10.1016/j.snb.2020.128973

59. Silva, C. F., Menezes, L. F., Pereira, A. C., & Nascimento, C. S. (2021). Molecularly Imprinted Polymer (MIP) for thiamethoxam: A theoretical and experimental study. Journal of Molecular Structure, 1231, 129980. doi: 10.1016/j.molstruc.2021.129980

60. El-Schich, Z., Zhang, Y., Feith, M., Beyer, S., Sternbæk, L., Ohlsson, L., Stollenwerk, M., & Wingren, A. G. (2020). Molecularly imprinted polymers in biological applications. BioTechniques, 69(6), 406–419. doi: 10.2144/btn-2020-0091

61. Piletsky, S., Canfarotta, F., Poma, A., Bossi, A. M., & Piletsky, S. (2020). Molecularly Imprinted Polymers for Cell Recognition. Trends in Biotechnology, 38(4), 368–387. doi: 10.1016/j.tibtech.2019.10.002

62. Iskierko, Z., Sharma, P. S., Prochowicz, D., Fronc, K., D’Souza, F., Toczydłowska, D., Stefaniak, F., & Noworyta, K. (2016). Molecularly Imprinted Polymer (MIP) Film with Improved Surface Area Developed by Using Metal–Organic Framework (MOF) for Sensitive Lipocalin (NGAL) Determination. ACS Applied Materials & Interfaces, 8(31), 19860–19865. doi: 10.1021/acsami.6b05515

63. Jolly, P., Tamboli, V., Harniman, R. L., Estrela, P., Allender, C. J., & Bowen, J. L. (2016). Aptamer–MIP hybrid receptor for highly sensitive electrochemical detection of prostate specific antigen. Biosensors and Bioelectronics, 75, 188–195. doi: 10.1016/j.bios.2015.08.043

64. Nottelet, P., Bataille, L., Gourgues, G., Anger, R., Lartigue, C., Sirand-Pugnet, P., Marza, E., Fronzes, R., & Arfi, Y. (2021). The mycoplasma surface proteins MIB and MIP promote the dissociation of the antibody-antigen interaction. Science Advances, 7(10). doi: 10.1126/sciadv.abf2403

65. De Middeleer, G., Dubruel, P., & De Saeger, S. (2016). Characterization of MIP and MIP functionalized surfaces: Current state-of-the-art. TrAC Trends in Analytical Chemistry, 76, 71–85. doi: 10.1016/j.trac.2015.11.007

66. Zhang, H. (2019). Molecularly Imprinted Nanoparticles for Biomedical Applications. Advanced Materials, 32(3). doi: 10.1002/adma.201806328

67. Preda, D., David, I. G., Popa, D.-E., Buleandra, M., & Radu, G. L. (2022). Recent Trends in the Development of Carbon-Based Electrodes Modified with Molecularly Imprinted Polymers for Antibiotic Electroanalysis. Chemosensors, 10(7), 243. doi: 10.3390/chemosensors10070243

68. Dong, X., Zhang, C., Du, X., & Zhang, Z. (2022). Recent Advances of Nanomaterials-Based Molecularly Imprinted Electrochemical Sensors. Nanomaterials, 12(11), 1913. doi: 10.3390/nano12111913

69. He, S., Zhang, L., Bai, S., Yang, H., Cui, Z., Zhang, X., & Li, Y. (2021). Advances of molecularly imprinted polymers (MIP) and the application in drug delivery. European Polymer Journal, 143, 110179. doi: 10.1016/j.eurpolymj.2020.110179

70. Mostafiz, B., Bigdeli, S. A., Banan, K., Afsharara, H., Hatamabadi, D., Mousavi, P., Hussain, C. M., Keçili, R., & Ghorbani-Bidkorbeh, F. (2021). Molecularly imprinted polymer-carbon paste electrode (MIP-CPE)-based sensors for the sensitive detection of organic and inorganic environmental pollutants: A review. Trends in Environmental Analytical Chemistry, 32, e00144. doi: 10.1016/j.teac.2021.e00144

71. Afsharara, H., Asadian, E., Mostafiz, B., Banan, K., Bigdeli, S. A., Hatamabadi, D., Keshavarz, A., Hussain, C. M., Keçili, R., & Ghorbani-Bidkorpeh, F. (2023). Molecularly imprinted polymer-modified carbon paste electrodes (MIP-CPE): A review on sensitive electrochemical sensors for pharmaceutical determinations. TrAC Trends in Analytical Chemistry, 160, 116949. doi: 10.1016/j.trac.2023.116949

72. Dabrowski, M., Lach, P., Cieplak, M., & Kutner, W. (2018). Nanostructured molecularly imprinted polymers for protein chemosensing. Biosensors and Bioelectronics, 102, 17–26. doi: 10.1016/j.bios.2017.10.045

73. Mustafa, Y. L., Keirouz, A., & Leese, H. S. (2022). Molecularly imprinted polymers in diagnostics: accessing analytes in biofluids. Journal of Materials Chemistry B, 10(37), 7418–7449. doi: 10.1039/d2tb00703g

72. Suzaei, F. M., Daryanavard, S. M., Abdel-Rehim, A., Bassyouni, F., & Abdel-Rehim, M. (2022). Recent molecularly imprinted polymers applications in bioanalysis. Chemical Papers, 77(2), 619–655. doi: 10.1007/s11696-022-02488-3

Fauzi, D., & saputri, F. A. (2019). Molecularly imprinted polymer nanoparticles (MIP-NPs) applications in electrochemical sensors. International Journal of Applied Pharmaceutics, 1–6. doi: 10.22159/ijap.2019v11i6.35088

76. Ali, G. K., & Omer, K. M. (2022). Molecular imprinted polymer combined with aptamer (MIP-aptamer) as a hybrid dual recognition element for bio(chemical) sensing applications. Review. Talanta, 236, 122878. doi: 10.1016/j.talanta.2021.122878

77. Refaat, D., Aggour, M. G., Farghali, A. A., Mahajan, R., Wiklander, J. G., Nicholls, I. A., & Piletsky, S. A. (2019). Strategies for Molecular Imprinting and the Evolution of MIP Nanoparticles as Plastic Antibodies—Synthesis and Applications. International Journal of Molecular Sciences, 20(24), 6304. doi: 10.3390/ijms20246304

78. Wisnuwardhani, H. A., Ibrahim, S., Mukti, R. R., & Damayanti, S. (2022). Molecularly-Imprinted SERS: A Potential Method for Bioanalysis. Scientia Pharmaceutica, 90(3), 54. doi: 10.3390/scipharm90030054

79. Karimi Baker, Z., & sardari, S. (2021). Molecularly Imprinted Polymer (MIP) Applications in Natural Product Studies Based on Medicinal Plant and Secondary Metabolite Analysis. Iranian Biomedical Journal, 25(2), 68–77. doi: 10.29252/ibj.25.2.68

80. Harito, C., Khalil, M., Septiani, N. L. W., Dewi, K. K., Hardiansyah, A., Yuliarto, B., & Walsh, F. C. (2022). Trends in nanomaterial-based biosensors for viral detection. Nano Futures, 6(2), 022005. doi: 10.1088/2399-1984/ac701d

81. Wang, L., Pagett, M., & Zhang, W. (2023). Molecularly imprinted polymer (MIP) based electrochemical sensors and their recent advances in health applications. Sensors and Actuators Reports, 5, 100153. doi: 10.1016/j.snr.2023.100153

82. Sun, P.-X., Cai, J., Chen, L.-J., Wang, J., & Yang, C. (2022). MIP-Based Portable Sensors for the Simultaneous Analysis of Multiple Food Additives. Food Analytical Methods, 15(8), 2335–2345. doi: 10.1007/s12161-022-02273-8

83. Raziq, A., Kidakova, A., Boroznjak, R., Reut, J., Öpik, A., & Syritski, V. (2021). Development of a portable MIP-based electrochemical sensor for detection of SARS-CoV-2 antigen. Biosensors and Bioelectronics, 178, 113029. doi: 10.1016/j.bios.2021.113029

84. Ramanavičius, S., Morkvėnaitė-Vilkončienė, I., Samukaitė-Bubnienė, U., Ratautaitė, V., Plikusienė, I., Viter, R., & Ramanavičius, A. (2022). Electrochemically Deposited Molecularly Imprinted Polymer-Based Sensors. Sensors, 22(3), 1282. doi: 10.3390/s22031282

85. Park, R., Jeon, S., Jeong, J., Park, S.-Y., Han, D.-W., & Hong, S. W. (2022). Recent Advances of Point-of-Care Devices Integrated with Molecularly Imprinted Polymers-Based Biosensors: From Biomolecule Sensing Design to Intraoral Fluid Testing. Biosensors, 12(3), 136. doi: 10.3390/bios12030136

86. Henry, O. Y. F., Cullen, D. C., & Piletsky, S. A. (2005). Optical interrogation of molecularly imprinted polymers and development of MIP sensors: a review. Analytical and Bioanalytical Chemistry, 382(4), 947–956. doi: 10.1007/s00216-005-3255-8

87. Shahhoseini, F., Azizi, A., & Bottaro, C. S. (2022). A critical evaluation of molecularly imprinted polymer (MIP) coatings in solid phase microextraction devices. TrAC Trends in Analytical Chemistry, 156, 116695. doi: 10.1016/j.trac.2022.116695

88. Cardoso, A. R., de Sá, M. H., & Sales, M. G. F. (2019). An impedimetric molecularly-imprinted biosensor for Interleukin-1β determination, prepared by in-situ electropolymerization on carbon screen-printed electrodes. Bioelectrochemistry, 130, 107287. doi: 10.1016/j.bioelechem.2019.04.017

89. Rebelo, T. S. C. R., Miranda, I. M., Brandão, A. T. S. C., Sousa, L. I. G., Ribeiro, J. A., Silva, A. F., & Pereira, C. M. (2021). A Disposable Saliva Electrochemical MIP-Based Biosensor for Detection of the Stress Biomarker α-Amylase in Point-of-Care Applications. Electrochem, 2(3), 427–438. doi: 10.3390/electrochem2030028

90. Uzun, L., & Turner, A. P. F. (2016). Molecularly-imprinted polymer sensors: realising their potential. Biosensors and Bioelectronics, 76, 131–144. doi: 10.1016/j.bios.2015.07.013

91. Kongintr, U., Lertanantawong, B., & Promptmas, C. (2023). A Label-Free Electrochemical Biosensor for Homocysteine Detection Using Molecularly Imprinted Polymer and Nanocomposite-Modified Electrodes. Polymers, 15(10), 2241. doi: 10.3390/polym15102241

92. Guan, G., Liu, B., Wang, Z., & Zhang, Z. (2008). Imprinting of Molecular Recognition Sites on Nanostructures and Its Applications in Chemosensors. Sensors, 8(12), 8291–8320. doi: 10.3390/s8128291

93. Liu, Y., Huang, S., Li, Z., & Zhao, M. (2015). Molecularly Imprinted Polymers as Tools for Bioassays and Biotransformation. Advances in Biochemical Engineering/Biotechnology, 207–226. doi: 10.1007/10_2015_315

94. Villa, C. C., Sánchez, L. T., Valencia, G. A., Ahmed, S., & Gutiérrez, T. J. (2021). Molecularly imprinted polymers for food applications: A review. Trends in Food Science & Technology, 111, 642–669. doi: 10.1016/j.tifs.2021.03.003

95. Sasaki, S., Ooya, T., Kitayama, Y., & Takeuchi, T. (2015). Molecularly imprinted protein recognition thin films constructed by controlled/living radical polymerization. Journal of Bioscience and Bioengineering, 119(2), 200–205. doi: 10.1016/j.jbiosc.2014.06.019

96. Pratiwi, R., Megantara, S., Rahayu, D., Pitaloka, I., & Hasanah, A. N. (2018). Comparison of Bulk and Precipitation Polymerization Method of Synthesis Molecular Imprinted Solid Phase Extraction for Atenolol using Methacrylic Acid. Journal of Young Pharmacists, 11(1), 12–16. doi: 10.5530/jyp.2019.11.3

97. Wei, S., Jakusch, M., & Mizaikoff, B. (2006). Capturing molecules with templated materials—Analysis and rational design of molecularly imprinted polymers. Analytica Chimica Acta, 578(1), 50–58. doi: 10.1016/j.aca.2006.06.077

98. Gonçalves, M. de L., Truta, L. A. N., Sales, M. G. F., & Moreira, F. T. C. (2021). Electrochemical Point-of Care (PoC) Determination of Interleukin-6 (IL-6) Using a Pyrrole (Py) Molecularly Imprinted Polymer (MIP) on a Carbon-Screen Printed Electrode (C-SPE). Analytical Letters, 54(16), 2611–2623. doi: 10.1080/00032719.2021.1879108

99. Pacheco, J. G., Rebelo, P., Freitas, M., Nouws, H. P. A., & Delerue-Matos, C. (2018). Breast cancer biomarker (HER2-ECD) detection using a molecularly imprinted electrochemical sensor. Sensors and Actuators B: Chemical, 273, 1008–1014. doi: 10.1016/j.snb.2018.06.113

100. Pasquardini, L., & Bossi, A. M. (2021). Molecularly imprinted polymers by epitope imprinting: a journey from molecular interactions to the available bioinformatics resources to scout for epitope templates. Analytical and Bioanalytical Chemistry, 413(24), 6101–6115. doi: 10.1007/s00216-021-03409-1

101. Mazouz, Z., Mokni, M., Fourati, N., Zerrouki, C., Barbault, F., Seydou, M., Kalfat, R., Yaakoubi, N., Omezzine, A., Bouslema, A., & Othmane, A. (2020). Computational approach and electrochemical measurements for protein detection with MIP-based sensor. Biosensors and Bioelectronics, 151, 111978. doi: 10.1016/j.bios.2019.111978

102. Cardoso, A. R., de Sá, M. H., & Sales, M. G. F. (2019). An impedimetric molecularly-imprinted biosensor for Interleukin-1β determination, prepared by in-situ electropolymerization on carbon screen-printed electrodes. Bioelectrochemistry, 130, 107287. doi: 10.1016/j.bioelechem.2019.04.017

103. Yarman, A., Turner, A. P. F., & Scheller, F. W. (2014). Electropolymers for (nano-)imprinted biomimetic biosensors. Nanosensors for Chemical and Biological Applications, 125–149. doi: 10.1533/9780857096722.1.125

104. Abbasy, L., Mohammadzadeh, A., Hasanzadeh, M., & Razmi, N. (2020). Development of a reliable bioanalytical method based on prostate specific antigen trapping on the cavity of molecular imprinted polymer towards sensing of PSA using binding affinity of PSA-MIP receptor: A novel biosensor. Journal of Pharmaceutical and Biomedical Analysis, 188, 113447. doi: 10.1016/j.jpba.2020.113447

105. Kalecki, J., Iskierko, Z., Cieplak, M., & Sharma, P. S. (2020). Oriented Immobilization of Protein Templates: A New Trend in Surface Imprinting. ACS Sensors, 5(12), 3710–3720. doi: 10.1021/acssensors.0c01634

106. Pan, M., Hong, L., Xie, X., Liu, K., Yang, J., & Wang, S. (2020). Nanomaterials‐Based Surface Protein Imprinted Polymers: Synthesis and Medical Applications. Macromolecular Chemistry and Physics, 222(1). doi: 10.1002/macp.202000222

107. Kato, M., Masuda, Y., Yoshida, N., Tosha, T., Shiro, Y., & Yagi, I. (2021). Impact of membrane protein-lipid interactions on formation of bilayer lipid membranes on SAM-modified gold electrode. Electrochimica Acta, 373, 137888. doi: 10.1016/j.electacta.2021.137888

108. Yan, X., Tang, J., Tanner, D., Ulstrup, J., & Xiao, X. (2020). Direct Electrochemical Enzyme Electron Transfer on Electrodes Modified by Self-Assembled Molecular Monolayers. Catalysts, 10(12), 1458. doi: 10.3390/catal10121458

109. Di Giulio, T., Mazzotta, E., & Malitesta, C. (2020). Molecularly Imprinted Polyscopoletin for the Electrochemical Detection of the Chronic Disease Marker Lysozyme. Biosensors, 11(1), 3. doi: 10.3390/bios11010003

110. Raziq, A., Kidakova, A., Boroznjak, R., Reut, J., Öpik, A., & Syritski, V. (2021). Development of a portable MIP-based electrochemical sensor for detection of SARS-CoV-2 antigen. Biosensors and Bioelectronics, 178, 113029. doi: 10.1016/j.bios.2021.113029

111. Wang, X., Li, J., & Chen, L. (2019). Advanced preparation technologies and strategies for molecularly imprinted materials. Chinese Science Bulletin, 64(13), 1352–1367. doi: 10.1360/n972018-00964

112. Phonklam, K., Wannapob, R., Sriwimol, W., Thavarungkul, P., & Phairatana, T. (2020). A novel molecularly imprinted polymer PMB/MWCNTs sensor for highly-sensitive cardiac troponin T detection. Sensors and Actuators B: Chemical, 308, 127630. doi: 10.1016/j.snb.2019.127630

113. Arshad, R., Rhouati, A., Hayat, A., Nawaz, M. H., Yameen, M. A., Mujahid, A., & Latif, U. (2020). MIP-Based Impedimetric Sensor for Detecting Dengue Fever Biomarker. Applied Biochemistry and Biotechnology, 191(4), 1384–1394. doi: 10.1007/s12010-020-03285-y

114. Jolly, P., Tamboli, V., Harniman, R. L., Estrela, P., Allender, C. J., & Bowen, J. L. (2016). Aptamer–MIP hybrid receptor for highly sensitive electrochemical detection of prostate specific antigen. Biosensors and Bioelectronics, 75, 188–195. doi: 10.1016/j.bios.2015.08.043

115. Tan, D., Li, F., & Zhou, B. (2020). Antifouling Self-Assembled Monolayers for Designing of Electrochemical Biosensors. International Journal of Electrochemical Science, 15(9), 9446–9458. doi: 10.20964/2020.09.56

116. Karami, P., Bagheri, H., Johari-Ahar, M., Khoshsafar, H., Arduini, F., & Afkhami, A. (2019). Dual-modality impedimetric immunosensor for early detection of prostate-specific antigen and myoglobin markers based on antibody-molecularly imprinted polymer. Talanta, 202, 111–122. doi: 10.1016/j.talanta.2019.04.061

117. Yola, M. L., Atar, N., & Erdem, A. (2015). Oxytocin imprinted polymer based surface plasmon resonance sensor and its application to milk sample. Sensors and Actuators B: Chemical, 221, 842–848. doi: 10.1016/j.snb.2015.07.004

118. Drzazgowska, J., Schmid, B., Süssmuth, R. D., & Altintas, Z. (2020). Self-Assembled Monolayer Epitope Bridges for Molecular Imprinting and Cancer Biomarker Sensing. Analytical Chemistry, 92(7), 4798–4806. doi: 10.1021/acs.analchem.9b03813

119. Yang, K., Li, S., Liu, L., Chen, Y., Zhou, W., Pei, J., Liang, Z., Zhang, L., & Zhang, Y. (2019). Epitope Imprinting Technology: Progress, Applications, and Perspectives toward Artificial Antibodies. Advanced Materials, 31(50). doi: 10.1002/adma.201902048

120. Wang, X., Chen, G., Zhang, P., & Jia, Q. (2021). Advances in epitope molecularly imprinted polymers for protein detection: a review. Analytical Methods, 13(14), 1660–1671. doi: 10.1039/d1ay00067e

121. Caserta, G., Zhang, X., Yarman, A., Supala, E., Wollenberger, U., Gyurcsányi, R. E., Zebger, I., & Scheller, F. W. (2021). Insights in electrosynthesis, target binding, and stability of peptide-imprinted polymer nanofilms. Electrochimica Acta, 381, 138236. doi: 10.1016/j.electacta.2021.138236

122. Dietl, S., Sobek, H., & Mizaikoff, B. (2021). Epitope-imprinted polymers for biomacromolecules: Recent strategies, future challenges and selected applications. TrAC Trends in Analytical Chemistry, 143, 116414. doi: 10.1016/j.trac.2021.116414

123. Khumsap, T., Corpuz, A., & Nguyen, L. T. (2021). Epitope-imprinted polymers: applications in protein recognition and separation. RSC Advances, 11(19), 11403–11414. doi: 10.1039/d0ra10742e

124. Zhao, Y., Simon, C., Daoud Attieh, M., Haupt, K., & Falcimaigne-Cordin, A. (2020). Reduction-responsive molecularly imprinted nanogels for drug delivery applications. RSC Advances, 10(10), 5978–5987. doi: 10.1039/c9ra07512g

125. Hou, H., Jin, Y., Xu, K., Sheng, L., Huang, Y., & Zhao, R. (2021). Selective recognition of a cyclic peptide hormone in human plasma by hydrazone bond-oriented surface imprinted nanoparticles. Analytica Chimica Acta, 1154, 338301. doi: 10.1016/j.aca.2021.338301

126. Khumsap, T., Bamrungsap, S., Thu, V. T., & Nguyen, L. T. (2021). Epitope-imprinted polydopamine electrochemical sensor for ovalbumin detection. Bioelectrochemistry, 140, 107805. doi: 10.1016/j.bioelechem.2021.107805

127. Ma, X.-T., He, X.-W., Li, W.-Y., & Zhang, Y.-K. (2019). Oriented surface epitope imprinted polymer-based quartz crystal microbalance sensor for cytochrome c. Talanta, 191, 222–228. doi: 10.1016/j.talanta.2018.08.079

128. Yang, K., Li, S., Liu, L., Chen, Y., Zhou, W., Pei, J., Liang, Z., Zhang, L., & Zhang, Y. (2019). Epitope Imprinting Technology: Progress, Applications, and Perspectives toward Artificial Antibodies. Advanced Materials, 31(50). doi: 10.1002/adma.201902048

129. Haupt, K., Medina Rangel, P. X., & Bui, B. T. S. (2020). Molecularly Imprinted Polymers: Antibody Mimics for Bioimaging and Therapy. Chemical Reviews, 120(17), 9554–9582. doi: 10.1021/acs.chemrev.0c00428

130. Pirzada, M., Sehit, E., & Altintas, Z. (2020). Cancer biomarker detection in human serum samples using nanoparticle decorated epitope-mediated hybrid MIP. Biosensors and Bioelectronics, 166, 112464. doi: 10.1016/j.bios.2020.112464


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